Waters has introduced the new Xevo™ TQ Absolute system, a sensitive and compact benchtop tandem mass spectrometer. It is up to 15× more sensitive for quantifying negatively ionising compounds than its predecessor and is smaller and uses less electricity and gas supply than other high-performance tandem quadrupole mass spectrometers. The Xevo TQ Absolute is designed to help pharmaceutical, food and beverage, and environmental analytical laboratories meet regulations requiring trace-level quantitative mass spectrometry analyses for a broad set of applications. New design features include guidance on optimal probe positioning for both sensitivity and robustness, and a source shield that helps minimise source contamination by the sample matrix or mobile phase salts.