Spectroscopy Since 1975
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Articles and Columns

Aerial photo of Silchester Roman settlement

This article describes how gamma-ray spectroscopy can reveal new features in buried archaeological sites. In her case at the Roman settlement of Silchester in Hampshire, UK, and other sites.

Article  |  Issue 34/6 (2022)
Diagram of reducing the background from pump and mobile phases

LC/MS/MS analysis of PFAS at ultra-trace levels requires mitigation to both liquid chromatograph and mass spectrometer to eliminate the leaching of fluorochemicals from components within the systems. Manual SPE configurations also require mitigative steps to eliminate any components constructed of PTFE to minimise or eliminate any PFAS contamination.

Article  |  Issue 34/6 (2022)
Diagram of scattering

This article describes a really interesting use of spectroscopic data processing from optical fibre cables.

Tony Davies Column  |  Issue 33/6 (2022)
Photo of confused person

“Error” and “uncertainty” are being used interchangeably and confusingly. This is “a scientific flaw of the first order”! However, Kim and Francis will put you right.

Sampling Column  |  Issue 34/6 (2022)
Four Generations of Quality timeline

John Hammond finishes his magnum opus on “Four Generations of Quality” with a look at what is science fiction and what is science fact. He considers what may turn out to be “fact” in the future for each of the preceding eight articles in the series.

QM Column  |  Issue 34/6 (2022)
Image of a prism splitting light

Non-linear spectroscopy can have various applications in different fields due to the accuracy and resolution it provides. This article describes a few possible applications that show the importance of non-linear spectroscopy.

Article  |  Issue / ()
Raman spectrum of aspirin

A Raman spectroscopy method was optimised to examine the chemical changes of aspirin tablets after interaction with helium temperatures.

Article  |  Issue 34/5 (2022)
Photo of the island where Viking remains were found

Sampling and Vikings seems to be the next unexpected connection within Kim Esbensen’s Sampling Column. Kim has been exploring an area of Southern Norway from where the founder of the Theory of Sampling, Pierre Gy, believed his ancestors originated. You will have to read the column to find the “smoking axe”! Oh, and there is an interesting report on the 10th World Conference on Sampling and Blending.

Sampling Column  |  Issue 34/5 (2022)
Logo from the ALI2004 conference

Tony Davies has started a timeline of significant spectroscopic system developments aligned with Queen Elizabeth’s reign as recently celebrated in her Platinum Jubilee. Jumping from Princess Anne the Princess Royal’s birth to Heinrich Kaiser certainly makes for a novel approach! Tony hopes that we can turn this into an online resource with your help.

Tony Davies Column  |  Issue 34/5 (2022)
Structure of ISO/TC 334 standards to ISO 17034

John Hammond has taken a break from his Four Generations magnum opus and reports on the recent meeting of the ISO technical committee on reference materials (ISO TC 334).

QM Column  |  Issue 34/5 (2022)
Scan of brain with various MS images from different regions

This article describes MALDI imaging’s potential uses in pathology applications, and the benefits of the technique to map hundreds of biomolecules (proteins, lipids and glycans, for example) in a label-free, untargeted manner or for imaging target proteins using a modified immunohistochemistry protocol, often from a single tissue section.

Article  |  Issue 34/4 (2022)
Images of metals in the brain

This article describes the use of synchrotron X-ray fluorescence and absorption spectroscopies to image metals in the brain.

Article  |  Issue 34/4 (2022)
Photo of entire crisps/chips and their crumbs

This column has invited two world-renowned experts in near infrared (NIR) spectroscopy to let the world benefit from decades of leading-edge experience, especially regarding sampling for quantitative NIR analysis.

Sampling Column  |  Issue 34/4 (2022)
Photo of quantum dots in tubes

This article looks at three related spectroscopic techniques/tools in the toolbox, namely, Fluorescence, near infrared (NIR) and Raman; and discuss the “what”, “where” and “how” of these techniques are being used to improve the quality of the measurement processes associated with them.

QM Column  |  Issue 34/4 (2022)

This column starts to answer the question, “how does one actually find FAIR data?” with a detailed example from Imperial College London.

Tony Davies Column  |  Issue 34/3 (2022)

Despite a multitude of chemical and physical methods capable of detecting fingerprint residues, there are substantial challenges with fingerprint recovery. Spectroscopic methods have played a critical role in the analysis of fingerprints, used to identify the chemical constituents present, examine their degradation over time and compare the chemical variation between donors.

Article  |  Issue 34/3 (2022)

The latest in this series of “Four Generations of Quality” considers the essential component that controls our modern instrument systems and the associated concept of data integrity that is fundamental to the quality of the data being generated.

QM Column  |  Issue 34/2 (2022)

Sampling is nothing more than the practical application of statistics. If statistics were not available, then one would have to sample every portion of an entire population to determine one or more parameters of interest. There are many potential statistical tests that could be employed in sampling, but many statistical tests are useful only if certain assumptions about the population are valid. Prior to any sampling event, the operative Decision Unit (DU) must be established. The Decision Unit is the material object that an analytical result makes inference to. In many cases, there is more than one Decision Unit in a population. A lot is a collection (population) of individual Decision Units that will be treated as a whole (accepted or rejected), depending on the analytical results for individual Decision Units. The application of the Theory of Sampling (TOS) is critical for sampling the material within a Decision Unit. However, knowledge of the analytical concentration of interest within a Decision Unit may not provide information on unsampled Decision Units; especially for a hyper-heterogenous lot where a Decision Unit can be of a completely different characteristic than an adjacent Decision Unit. In cases where every Decision Unit cannot be sampled, application of non-parametric statistics can be used to make inference from sampled Decision Units to Decision Units that are not sampled. The combination of the TOS for sampling of individual Decision Units along with non-parametric statistics offers the best possible inference for situations where there are more Decision Units than can practically be sampled.

Sampling Column  |  Issue 34/2 (2022)

This article is about photoacoustic imaging and spectroscopy, and their use for looking inside us, where they have a number of benefits. Hilde Jans and Xavier Rottenberg explain the fundamentals and how new technology may be bringing a new photoacoustics age.

Article  |  Issue 34/1 (2022)

Tony Davies marks the passing of Svante Wold, who gave us “chemometrics”. It all started with a grant application!

Tony Davies Column  |  Issue 34/1 (2022)