Surface-enhanced Raman spectroscopy (SERS) active sensing assays in conjunction with the availability of highly sensitive compact Raman spectrometers offer great promise for implantable biosensors. In this application note, we explore the potential of SERS to improve on fluorescence-based biosensors, looking at one research group’s innovative sensor design as they study the influence of the supporting hydrogel matrix material on pH assay performance. The study looked at response to pH in a simulated in vivo continuous monitoring environment, with multiple cycles between pH 4, 7 and 10. The results revealed implications for selectivity, stability and reversibility, all of which are essential to creating the ideal implantable sensor.
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