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ATR analysis of the relative concentrations of active pharmaceutical ingredients

lnfrared quantitative analyses are an everyday requirement in the analytical laboratory. While liquid solutions are commonly analysed, mixtures of powdered components also exist and often require quantitative analysis without dissolution into a solvent. The traditional infrared analysis method for powdered samples is the collection of a KBr pellet spectrum of an aliquot of the powdered sample. However, preparation of KBr pellets requires skill and precise weighing of every component for each sample. The Golden Gate™ single reflection diamond ATR provides a simple and effective alternative, suitable for the infrared analysis of powders. ATR analysis is less complicated than using KBr pellets, is fast and only requires a very small amount of the sample.