Informing Spectroscopists for Over 40 Years

Ion Mobility

What developments do you need to work more efficiently?

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Tony Davies continues his quest to find out what you all need to work more efficiently. You will remember that in the last issue, Tony introduced his survey to discover what developments were needed in spectroscopy by readers. Some of the initial responses are explored, and Tony finds that he has opened a “can of worms”.

Travelling-wave ion mobility mass spectrometry elucidates gold-binding sites of drugs

Drugs containing gold have been used for centuries to treat conditions like rheumatoid arthritis. In addition, they can be effective against cancer and HIV. One mechanism by which they work could occur because gold ions force the zinc ions out of zinc fingers—looped, nucleic acid binding protein domains. American researchers have characterised such “gold fingers” using ion mobility mass spectrometry and identified the exact gold binding sites.

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