Mass spectrometry Imaging
The new Proteoform Profiling™ 1.0 solution from Bruker enables the systematic, large-scale, label-free study of all expressed proteoforms.
By measuring the height profile of the sample prior to analysis, mass spectrometry imaging can now visualise the distribution of chemical substances on samples with non-flat surfaces.
University of Alabama at Birmingham, USA, researchers have made a microscopic snapshot of the early renal lipid changes in acute kidney injury, using matrix-assisted laser desorption/ionisation (MALDI) tissue imaging to localise the changes.
After an introduction to MALDI, DESI and SIMS, the authors describe their main applications in forensics, as well as the advantages provided in terms of sample preparation over approaches routinely used in toxicological laboratories.
Researchers have used mass spectrometry imaging to uncover exactly how a human egg captures an incoming sperm to begin the fertilisation process.