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Mass spectrometry MALDI ToF

Benchtop MALDI-TOF mass spectrometer

Shimadzu Scientific Instruments have released the MALDI-8020 benchtop MALDI-TOF mass spectrometer. The MALDI-8020 has a newly designed load-lock system for rapid sample target introduction and a solid-state laser for fast data acquisition speeds. Using linear time-of-flight, it enables low-level detection of proteins, peptides and polymers, among other analytes. In addition, it accommodates standard laboratory workflows such as peptide mass finger printing for simple protein ID confirmation, in-source decay (ISD) and polymer distribution analysis.

MALDI PharmaPulse 2.0

This is a system for pharmaceutical label-free ultra-high-throughput screening (UHTS) for primary screens of millions of compounds. It can measure up to 10 different samples per second and integrates with third-party UHTS robotics for automated handling of up to 6144-well sample plates. It is based on Bruker’s rapiflex MALDI time-of-flight mass spectrometer.

MALDI Colonyst

Robotic system to pick bacterial colonies and deposit them on MALDI target plates. Selection of colonies can be manual or automatic, and colonies can be preselected based on size and colour discrimination. A patented liquid deposition method enables a significant increase of MALDI-TOF microbial identification scores. The preparation process is documented with photos at all key stages to provide traceability.

Analysis and sequencing of nucleic acids by matrix-assisted laser desorption/ionisation mass spectrometry

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This article gives a most useful overview of the analysis and sequencing of nucleic acids by matrix-assisted laser desorption/ionisation mass spectrometry, which should interest all readers and may well serve as a useful tutorial article.

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