Drugs containing gold have been used for centuries to treat conditions like rheumatoid arthritis. In addition, they can be effective against cancer and HIV. One mechanism by which they work could occur because gold ions force the zinc ions out of zinc fingers—looped, nucleic acid binding protein domains. American researchers have characterised such “gold fingers” using ion mobility mass spectrometry and identified the exact gold binding sites.
Waters’ Vion IMS QTof mass spectrometer combines high-resolution tandem spectrometry and ion mobility separation in a bench-top instrument.Waters’ Vion IMS QTof mass spectrometer combines high-resolution tandem spectrometry and ion mobility separation in a bench-top instrument.
Antony Neil Daviesa and Jörg Ingo BaumbachbaExternal Professor, University of Glamorgan, UK. Director, ALIS Ltd, and ALIS GmbH–Analytical Laboratory Informatics SolutionsbISAS–Institute for Analytical Sciences, Metabolomics Department, Bunsen-Kirchhoff-Str. 11, 44139 Dortmund, Germany
GE Security has introduced MobileTrace, a user-friendly trace detection instrument that enables simultaneous explosives and narcotics detection in a handheld device. It facilitates detection of both narcotics and explosives in seconds and also increases the range of explosives detectable from a single sample. The simultaneous dual-mode detection, combined with an improved battery for long life. Based on the company's ion trap mobility spectrometry platform, MobileTrace is a reliable detection tool in a lightweight package that is compact and easy to use, with a contemporary data display and touch-screen user interface.GE Security, IncIssue: 19/06 RSN:
Burle Electro-Optics has been awarded patent 7,081,618 for resistive glass drift tubes in ion mobility spectrometers. This details simplification in manufacture with single-piece construction and reduction in number of parts used in such spectrometers. www.burle.com
Pittcon 2007 has launched a new, re-designed website. www.pittcon.org
Tags: Atomic absorption Atomic emission ICP-MS Luminescencefluorescence Infrared Near infrared Mass spectrometry Laser spectroscopy NMR ESR EPR Raman Surface analysis UVvis X-ray spectrometry Atomic fluorescence RMs and standards Far infrared Gamma-ray Imaging Ion mobility MRI Mobile Plasma Polarimetry Process Related equipment Sampling Separation science Software Spectroradiometry X-ray diffraction Microscopy Chemometrics Terahertz
Sionex, a company commercialising chemical and biological sensors and systems, announced at the 15th International Society for Ion Mobility Spectrometry meeting an Early Technology Access Programme for its microAnalyzer system. This will enable user and potential OEMs to investigate applications. www.sionex.com
Smiths Detection’s Ionscan 500DT portable desktop trace detection system has met the certification standards set by the Transportation Security Administration having met its performance criteria for Explosives Trace Detection Systems. www.smithsdetection.com
Bruker Daltonics has received a Product Innovation Award from Frost & Sullivan in recognition of Bruker’s contributions to a broad array of mass spectrometry technologies and for its commitment to the growing field of proteomics. www.bruker-biosciences.com
Bruker Daltonics NBC Detection has received certification form the US Department of Homeland Security for its RAID-M hand-held chemical detector. www.bruker-biosciences.com
Isonics has signed a development agreement with DualDraw to create and test a prototype that combines a version of Isonics’ ion mobility spectroscopy (IMS) technology with DualDraw’s Mailroom Inspection Workstations. The workstations keep toxic substances away from the breathing zone of workers sorting or opening mail and the IMS will provide an alarm if toxic or explosive substances are detected. www.isnics.com, www.dualdraw.com
A new technique based on differential mobility spectrometry (DMS), a development of ion mobility spectrometry, is being developed by Dr Paul Thomas and colleagues at the University of Manchester to treat hospital patients with lung disease. The aim is, according to Dr Thomas, that “…one day we will be able to detect a previously undetectable tumour metabolising inside a human lung simply by asking the patient to breathe into a device like this”. “The potential is such that we will not only be able to provide more accurate diagnosis, but we will be able to tailor treatments to the individual. For instance, if a patient is taking steroids for asthma, we would be able to determine whether they were being given the right amount of steroids from the molecules in their breath which relate to the severity of the inflammation in their lungs.”
This research will form part of the new UK National Initiative in Ion Mobility Spectrometry [see Spectrosc. Europe 17(4), (2005)].
A new national initiative in ion mobility spectrometry (IMS) which aims to explore the use of IMS measurement within the pharmaceutical and biomedical fields has been launched in the UK. Professor Colin Creaser from Nottingham Trent University and Dr Paul Thomas from the University of Manchester are leading a consortium of experts and industrial partners, who will evaluate the potential of IMS in areas such as high-speed separations of complex mixtures and structural characterisation of pharmaceuticals and biomolecules.
This initiative will create a platform for a programme of internationally competitive research. As well as the two lead universities, GlaxoSmithKline, AstraZeneca and Waters have pledged their support. So far £530,000 has been committed to the initiative.
Colin Creaser commented that “We are at an important crossroad in the development of IMS from applications principally in the security field to a technique used widely in pharmaceutical discovery and biomedical diagnostics”.
Smiths Detection is to supply the UK Ministry of Defence with Lightweight Chemical Agent Detectors (LCAD) under a contract worth some £20 million. LCADs combine ion mobility spectrometry with corona discharge and can be worn by troops or attached to personal equipment. www.smithsdetection.com